Do Women Need to "Replace" Hormones?
In recent years, many women have stopped taking hormone replacement therapy because of growing evidence that the risks outweigh the benefits for most women. However, millions still struggle with the decision: should I go on, should I stay on, or should I go off?
For decades, women were told that hormone therapy was like a fountain of youth that would protect them against many of the diseases and symptoms of aging that increase after menopause. Since estrogen alone was known to increase the risk of uterine cancer, doctors usually prescribed a combination of estrogen and progestin, unless a woman had a hysterectomy and therefore was at no risk of uterine cancer.
In addition to its proven effectiveness for decreasing hot flashes, night
sweats, and vaginal dryness, in the 1980's and 1990's hormone therapy was
thought to decrease osteoporosis, prevent heart disease, improve memory and
concentration, reduce wrinkles, and improve mood. Women were encouraged to
start hormone therapy before menopause started and to continue to take it
for years, if not decades, in order to improve their health and their quality
of life.
What the Research Says
Research shows that, "replacing" the hormones women lose as they age is not
only unnecessary, but it can bad for your health. The Women's Health Initiative
(WHI), sponsored by the National Institutes of Health (NIH), enrolled over
27,000 women in three different trials to study the effect of hormones on
women's bodies. The 3 trials were: 1) the Estrogen Plus Progestin Trial, 2)
the Women's Health Initiative Memory Study, and 3) the Estrogen-alone Trial.
The researchers found that women taking a combination of estrogen and progesterone
hormones were more likely to develop breast cancer, stroke, and blood clots, and at least as likely to develop heart disease, compared to women taking
placebo. Those on estrogen alone were at an increased risk for strokes and
at a significantly increased risk for deep vein, thrombosis.1
The memory Study revealed that women taking a combination of estrogen plus
progesterone were twice as likely to develop Alzheimer's Disease and other
forms of dementia compared to women on placebo.
All the three trials were stopped early for ethical reasons when it became clear that women taking hormones were more likely to be harmed than helped. While there are some short-term benefits to taking hormones, the researchers concluded that for most women, the risks of hormone therapy outweigh the benefits.
In 2009, a new study found that hormone therapy increased the risk of dying of lung cancer among women who smoked or previously smoked, compared to smokers or former smokers who did not take hormone therapy. For more information click here.
What are the Risks and Benefits of Hormone Therapy?
To emphasize that lost hormones don't necessarily need to be replaced, the term "hormone replacement therapy" has been changed to "hormone therapy." Experts now advise women to use hormone therapy only for severe symptoms of menopause that reduce the quality of life, such as severe hot flashes, night sweats, insomnia, and vaginal dryness. Women are urged to take hormones at the lowest dose that is effective and for the shortest possible period of time. However, even short-term use (less than one year) increases some risks; for example, the increase in heart disease comes primarily from the first year of hormone use.
Hormone therapy may be recommended in severe cases of vulvar and vaginal
atrophy2 as well as for treating severe postmenopausal
osteoporosis when non-estrogen medications or other strategies are unsuccessful
or impossible. A decision to use any combination of estrogen and progestin
should be discussed with a physician who is expert on the topic, and specific
criteria for the indication, dose, and duration of these hormones must be
met prior to their prescription and administration.
Risks:
Compared to women taking placebo, within 5 years the women who received
estrogen plus progestin experienced:
-- 41% more strokes
-- 29% more heart attacks
-- twice as many blood clots
-- 22% more heart disease of all types
-- 26% more breast cancer
-- 37% fewer cases of colorectal cancer
-- one-third fewer hip fractures
-- 24% fewer bone fractures of any type
-- no difference in the overall death rate
It's important to note that only 2.5% of the women in the study experienced health problems. So, while the percentage increase in some diseases was rather large, the risk for most patients remained relatively small. That does not mean these risks are not important however.
To provide a better sense of the additional risks that
come with combination hormone therapy, the study data can be summarized
more simply. Compared to a group of 10,000 women taking placebo, 10,000
women taking combination hormone therapy will experience:
-- 7 more heart attacks
-- 8 more strokes
-- 8 more cases of breast cancer
-- 18 more blood clots
-- 6 fewer cases of colorectal cancer
-- 5 fewer hip fractures
Research Evidence
The Women's Health Initiative was a major 15-year research program to address the most common causes of death, disability and poor quality of life in post-menopausal women - cardiovascular disease, cancer, and osteoporosis. The WHI was launched in 1991 and consisted of a set of clinical trials and an observational study. The clinical trials were designed to test the effects of post-menopausal hormone therapy, diet modification, and calcium and vitamin D supplements on heart disease, fractures, and breast and colorectal cancer.
The hormone trial had two studies: the estrogen-plus-progestin
study of women with a uterus and the estrogen-alone study
of women without a uterus. (Women with a uterus were given progestin in
combination with estrogen, a practice known to prevent endometrial cancer.)
In both hormone therapy studies, women were randomly assigned to either
the hormone medication being studied or to placebo. Those studies ended
several years ago, and the women are now participating in a follow-up phase,
which will last until 2010.
Estrogen plus Progestin Trial (stopped in July 2002)
Compared with women in the placebo those on estrogen plus progestin had:
- Increased risk of heart attack
- Increased risk of stroke
- Increased risk of blood clots>
- Increased risk of breast cancer
- Reduced risk of colorectal cancer
- Fewer fractures
- No protection against mild cognitive impairment and increased risk of dementia (study included only women 65 and older)
- Increased risk of dying of lung cancer
Women's Health Initiative Memory Study (stopped in May 2003)
- Women taking hormones had twice the risk for developing dementia
- Hormones provided no protection against mild cognitive impairment/memory loss
Estrogen-alone Trial (stopped in February 2004)
- Estrogen increased risk for stroke
- Estrogen decreased risk for hip fracture
- No positive or negative effect on breast cancer
Compared to placebo women on estrogen alone had:
- Increased risk of stroke
- Increased risk of blood clots
- Uncertain effect for breast cancer
- No difference in risk for colorectal cancer
- No difference in risk for heart attack
- Reduced risk of fracture
Links to Research Information
Estrogen
Plus Progestin Trial: July 2002
The Women's Health
Initiative Memory Study: May 2003
The
Estrogen-alone Trial: February 2004
1. Deep vein thrombosis refers to a blood clot deep inside the veins, usually in the legs.
2. Symptoms include thinning and inflammation of the vaginal walls and changes in the vulva.
